Information for Veterinarians
Fipronil, the active ingredient in EasySpot™, is the most popular adulticide in small veterinary medicine due to its broad spectrum of activity, excellent safety profile and its long residual performance. The efficacy and safety of the molecule has been well-established since its development in the mid-1990s and is still widely used today in Frontline® Top Spot® and Frontline® Spray Treatment. For more detailed information, view the fact sheet.
How Does It Work?
Fipronil interacts with gamma aminobutyric acid (GABA)-gated and glutamate-gated chloride channels in the nervous systems of target species. It blocks inhibitory nerve transmission in susceptible ectoparasites, leading to hyperexcitability and death.
Indications
Fipronil is an ectoparasiticide that is effective against insects and some members of the order Acarina (e.g., ticks and mites). The two ectoparasites most often targeted by pet formulations are fleas and ticks. Fipronil is also active against mites that cause sarcoptic mange and chewing lice.
Chemical and Physical Properties
Fipronil’s high lipophilicity and low water solubility play important roles in its residual efficacy. Fipronil is much less soluble in water than the active ingredients in competitive products, so it is less likely to be washed off.
Efficacy
Fipronil has been shown to
- Kill ticks and fleas quickly
- Remain effective between applications
Product Uses
Fipronil can be used on cats and kittens 8 weeks of age and older (EasySpot), and on dogs and puppies 8 weeks of age and older (Parastar).
Pet owners should be reminded to
- Read and follow label directions on the product package.
- Make sure to use the appropriate product for the pet. It is especially important to avoid using a dog product on a cat.
- Check with a veterinarian before using a flea and tick product on a debilitated, aged or medicated pet.